Monoamine Oxidase Inhibitor (MAOI)

an inhibitor of one of the enzymes that degrades and thereby inactivates monoamine neurotransmitters. MAOIs act irreversibly and nonselectively. Includes medication such as phenelzine (Nardil), tranylcypromine (Parnate), and isocarboxazid (Marplan). Phenelzine is perhaps the most commonly prescribed MAOI for anxiety disorders. Generic names for MAOIs include brofaromine , isocarboxazid, moclobemide, pargyline, phenelzine, selegeline, tranylcypromine,. These medications are used much less than previously because the SSRIs, and other agents have been found to be as effective and the MAOIs have been associated with serious side effects. People who use MAOI medications have to adhere to a very strict diet that excludes all foods that contain high concentrations of certain dietary amino acids, such as tyramine, that are ordinarily degraded by monoamine oxidase enzymes.